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Article

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.

Nature biotechnology - 1 Aug 2012

Lippmann Ethan S, Azarin Samira M, Kay Jennifer E, Nessler Randy A, Wilson Hannah K, Al-Ahmad Abraham, Palecek Sean P, Shusta Eric V

Abstract excerpt

The blood-brain barrier (BBB) is crucial to the health of the brain and is often compromised in neurological disease. Moreover, because of its barrier properties, this endothelial interface restricts uptake of neurotherapeutics. Thus, a renewable source of human BBB endothelium could spur brain r...

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PMID: 22729031
DOI: 10.1038/nbt.2247
PMCID: PMC3467331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22729031-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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