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Article

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells.

Science advances - 1 Nov 2017

Qian Tongcheng, Maguire Shaenah E, Canfield Scott G, Bao Xiaoping, Olson William R, Shusta Eric V, Palecek Sean P

Abstract excerpt

The blood-brain barrier (BBB) is composed of specialized endothelial cells that are critical to neurological health. A key tool for understanding human BBB development and its role in neurological disease is a reliable and scalable source of functional brain microvascular endothelial cells (BMECs). Human pluripotent stem cells (hPSCs) can theoretically generate unlimited quantities of any cell lineage in vitro,...

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Identifiers

PMID: 29134197
DOI: 10.1126/sciadv.1701679
PMCID: PMC5677350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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