Article

Replication protein A binds RNA and promotes R-loop formation

2020-02-12

Abstract excerpt

<h4>SUMMARY</h4> Replication protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for all metabolic processes that involve ssDNA including DNA replication, repair, and damage signaling. Surprisingly, we found here that RPA binds RNA in vitro with high affinity. Using native RIP method, we isolated RNA-RPA complexes from human cells. Furthermore, RPA promotes R-loop formation between RNA and ho...

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Literature Corpus work: b8bedb87-c8db-5e8f-a0e8-c2f6b8276e90
DOI: 10.1101/2020.02.11.943977

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