Article

S phase R-loop formation is restricted by PrimPol-mediated repriming

2018-05-09

Abstract excerpt

<h4>Summary</h4> During DNA replication, conflicts with ongoing transcription are frequent and require careful management to avoid genetic instability. R-loops, three stranded nucleic acid structures comprising a DNA:RNA hybrid and displaced single stranded DNA, are important drivers of damage arising from such conflicts. How R-loops stall replication and the mechanisms that restrain their formation during S phas...

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Literature Corpus work: 33433b44-4ee6-56c7-bdae-19420e374352
DOI: 10.1101/318220

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