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Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responses

7 Mar 2006

Abstract excerpt

Human replication protein A (RPA), a heterotrimeric protein complex, was originally defined as a eukaryotic single-stranded DNA binding (SSB) protein essential for the in vitro replication of simian virus 40 (SV40) DNA. Since then RPA has been found to be an indispensable player in almost all DNA metabolic pathways such as, but not limited to, DNA replication, DNA repair, recombination, cell cycle, and DNA damage...

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PMID: 16523492
DOI: 10.1002/jcp.20622

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