Article

Human primosome requires replication protein A when copying DNA with inverted repeats

2024-03-11

Abstract excerpt

<h4>ABSTRACT</h4> The human primosome, a four-subunit complex of primase and DNA polymerase alpha (Polα), initiates DNA synthesis on both chromosome strands by generating chimeric RNA-DNA primers for loading DNA polymerases delta and epsilon (Polε). Replication protein A (RPA) tightly binds to single-stranded DNA strands, protecting them from nucleolytic digestion and unauthorized transactions. We report here tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc6e5f01-c808-5d58-ab4e-3b1ef3cef820
DOI: 10.1101/2024.03.11.584335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human primosome requires replication protein A when copying DNA with inverted repeatsDOI 10.1101/2024.03.11.584335Read

Replication protein A binds RNA and promotes R-loop formationSemantic proximity Read

Replication Protein A, the Main Eukaryotic Single-Stranded DNA Binding Protein, a Focal Point in Cellular DNA MetabolismSemantic proximity Read

S phase R-loop formation is restricted by PrimPol-mediated reprimingSemantic proximity Read

DNA polymerase α-primase can function as a translesion DNA polymeraseSemantic proximity Read

Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.Semantic proximity Read

Structure of the human RNA Polymerase I Elongation ComplexSemantic proximity Read

Actin nucleation safeguards single-stranded DNA and promotes replication fork protectionSemantic proximity Read

Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.Semantic proximity Read

Structural elements required for the efficient loading and activation of HELB on RPA-coated single-stranded DNASemantic proximity Read

The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break RepairSemantic proximity Read

Protein-mediated stabilization and nicking of the non-template DNA strand dramatically affect R-loop formation <i>in vitro</i>Semantic proximity Read

Structural Analysis of Strand Misalignment during DNA Synthesis by a Human DNA PolymeraseSemantic proximity Read