Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break Repair

27 Jan 2024

Abstract excerpt

Human Replication Protein A (RPA) was historically discovered as one of the six components needed to reconstitute simian virus 40 DNA replication from purified components. RPA is now known to be involved in all DNA metabolism pathways that involve single-stranded DNA (ssDNA). Heterotrimeric RPA comprises several domains connected by flexible linkers and is heavily regulated by post-translational modifications...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38397158
DOI: 10.3390/genes15020167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break RepairPMID 38397158Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

Replication Protein A, the Main Eukaryotic Single-Stranded DNA Binding Protein, a Focal Point in Cellular DNA MetabolismSemantic proximity Read ↗

Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication CentersSemantic proximity Read ↗

Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.Semantic proximity Read ↗

Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA).Semantic proximity Read ↗

Replication protein A binds RNA and promotes R-loop formationSemantic proximity Read ↗

Human replication protein A (RPA) binds a primer-template junction in the absence of its major ssDNA-binding domains.Semantic proximity Read ↗

Actin nucleation safeguards single-stranded DNA and promotes replication fork protectionSemantic proximity Read ↗

Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Semantic proximity Read ↗

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Semantic proximity Read ↗

Dynamic binding of replication protein a is required for DNA repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.