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Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repair

24 Jan 2011

Abstract excerpt

Replication protein A (RPA), the eukaryotic single-strand deoxyribonucleic acid (DNA [ss-DNA])-binding protein, is involved in DNA replication, nucleotide damage repair, mismatch repair, and DNA damage checkpoint response, but its function in DNA double-strand break (DSB) repair is poorly understood. We investigated the function of RPA in homology-dependent DSB repair using Xenopus laevis nucleoplasmic extracts...

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PMID: 21263027
DOI: 10.1083/jcb.201005110

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