Article

Fluorescent human RPA to track assembly dynamics on DNA

2023-11-23

Abstract excerpt

DNA metabolic processes including replication, repair, recombination, and telomere maintenance occur on single-stranded DNA (ssDNA). In each of these complex processes, dozens of proteins function together on the ssDNA template. However, when double-stranded DNA is unwound, the transiently open ssDNA is protected and coated by the high affinity heterotrimeric ssDNA binding Replication Protein A (RPA). Almost all d...

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Literature Corpus work: 44da0186-c58b-5ad4-ad42-e2f432480b31
DOI: 10.1101/2023.11.23.568455

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