Article

DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43

2022-11-15

Abstract excerpt

Protein misfolding and aggregation are characteristic features of neurodegenerative diseases. While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that highly disordered, hydrophilic and charged heat-resistant obscure (Hero) proteins may have similar effects. Specifically, Hero proteins can maintain the activity of other proteins from denaturing conditions in vitro,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b84e8a94-940a-5944-ad6e-c3ad1450fd6f
DOI: 10.1101/2022.11.15.516569

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43DOI 10.1101/2022.11.15.516569Read

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.Semantic proximity Read

Structural Insights Into TDP-43 and Effects of Post-translational ModificationsSemantic proximity Read

The mutational landscape of a prion-like domainSemantic proximity Read

The mutational landscape of a prion-like domainSemantic proximity Read

An ALS-associated mutation in the C-terminal α-helix of TDP-43 uncouples condensate formation and amyloid assembly.Semantic proximity Read

DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.Semantic proximity Read

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.Semantic proximity Read

Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43.Semantic proximity Read

An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen BondsSemantic proximity Read

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicitySemantic proximity Read

Circular RNA aptamers act as superb sub-stoichiometric chaperones to prevent cytosolic TDP-43 condensationSemantic proximity Read

Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion proteinSemantic proximity Read