Article

The mutational landscape of a prion-like domain

2019-03-31

Abstract excerpt

Specific insoluble protein aggregates are the hallmarks of many neurodegenerative diseases 1–5 . For example, cytoplasmic aggregates of the RNA-binding protein TDP-43 are observed in 97% of cases of Amyotrophic Lateral Sclerosis (ALS) 6,7 . However, it is still unclear for ALS and other diseases whether it is the insoluble aggregates or other forms of the mutated proteins that cause these diseases that are actua...

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Literature Corpus work: 7c368d03-a56e-5d86-968d-d82b4163f910
DOI: 10.1101/592121

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