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Article

The mutational landscape of a prion-like domain

13 Sept 2019

Abstract excerpt

Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause cellular toxicity is still not clear, even in simpler cellular systems. We reasoned that deep mutagenesis might be a powerful approach to disentangle the relationship between aggregation and...

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PMID: 31519910
DOI: 10.1038/s41467-019-12101-z

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