Article
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.
Structure (London, England : 1993) - 6 Jun 2024
Ryder Bryan D, Ustyantseva Elizaveta, Boyer David R, Mendoza-Oliva Ayde, Kuska Mikołaj I, Wydorski Paweł M, Macierzyńska Paulina, Morgan Nabil, Sawaya Michael R, Diamond Marc I, Kampinga Harm H, Joachimiak Lukasz A
Abstract excerpt
J-domain protein (JDP) molecular chaperones have emerged as central players that maintain a healthy proteome. The diverse members of the JDP family function as monomers/dimers and a small subset assemble into micron-sized oligomers. The oligomeric JDP members have eluded structural characterization due to their low-complexity, intrinsically disordered middle domains. This in turn, obscures the biological...
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