Article

Circular RNA aptamers act as superb sub-stoichiometric chaperones to prevent cytosolic TDP-43 condensation

2026-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Pathological protein misfolding and aggregation underlie many devastating human diseases, yet strategies to selectively neutralize aggregation-prone protein states without perturbing their normal functions remain limited. Here we identify loosely structured circular RNA (cRNA) aptamers, circT3 and its minimized 116-nt variant circT3-M3, as superb sub-stoichiometric RNA chaperones that suppress p...

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Literature Corpus work: 912cda58-16d8-5d78-ac03-2fd6699991d1
DOI: 10.64898/2026.06.01.729436

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