Article
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nature structural & molecular biology - 1 Jun 2018
Guenther Elizabeth L, Cao Qin, Trinh Hamilton, Lu Jiahui, Sawaya Michael R, Cascio Duilio, Boyer David R, Rodriguez Jose A, Hughes Michael P, Eisenberg David S
Abstract excerpt
The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-complexity domain (LCD) is believed to be involved in both types of aggregation. To uncover the structural origins of these two modes of β-sheet-rich aggregation, we have determined ten structures of segments of the LCD of human TDP-43. Six of...
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