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Article

An ALS-associated mutation in the C-terminal α-helix of TDP-43 uncouples condensate formation and amyloid assembly.

Protein science : a publication of the Protein Society - 1 May 2026

Byrd Emily J, Crossley Joel A, Chau Chalmers C C, Actis Paolo, Calabrese Antonio N

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP-43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed of solely its intrinsically disordered C-terminal domain (CTD)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41969219
DOI: 10.1002/pro.70565
PMCID: PMC13071763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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