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Article

Structural Insights Into TDP-43 and Effects of Post-translational Modifications

17 Dec 2019

Abstract excerpt

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative diseases. In this review, we have gathered and presented structural information on the different regions of TDP-43 with high resolution structures available. A thorough understanding of TDP-43 structure, effect of modifications, aggregation and sites of localization is necessary as we develop therapeutic strategies targeting...

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Identifiers

PMID: 31920533
DOI: 10.3389/fnmol.2019.00301

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