Article

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity

2025-05-10

Abstract excerpt

Cytoplasmic aggregation and concomitant dysfunction of the prion-like, RNA-binding protein TDP-43 underpin several fatal neurodegenerative diseases, including amyotrophic lateral sclerosis. To elucidate endogenous defenses, we systematically scoured the entire human Hsp70 network for buffers of TDP-43 toxicity. We identify 30 J-domain proteins (2 DNAJAs, 10 DNAJBs, 18 DNAJCs), 6 Hsp70s, and 5 nucleotide-exchange f...

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Literature Corpus work: 1e4f07a8-7b3f-5bda-8b95-a35ccc18c2f2
DOI: 10.1101/2025.05.10.653282

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