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Article

Liquid‒liquid phase separation: roles and implications in future cancer treatment.

International journal of biological sciences - 1 Jan 2023

Liu Zheran, Qin Zijian, Liu Yingtong, Xia Xi, He Ling, Chen Na, Hu Xiaolin, Peng Xingchen

Abstract excerpt

Liquid‒liquid phase separation (LLPS) is a phenomenon driven by weak interactions between biomolecules, such as proteins and nucleic acids, that leads to the formation of distinct liquid-like condensates. Through LLPS, membraneless condensates are formed, selectively concentrating specific proteins while excluding other molecules to maintain normal cellular functions. Emerging evidence shows that cancer-related...

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Identifiers

PMID: 37705755
DOI: 10.7150/ijbs.81521
PMCID: PMC10496506

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