Article

Landscape of super-enhancers in small cell carcinoma of the ovary, hypercalcemic type and efficacy of targeting with natural product triptolide

2023-09-10

Abstract excerpt

<h4>Purpose</h4> Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare form of ovarian cancer affecting young women and girls. SCCOHT is driven by loss of both SWI/SNF ATPases SMARCA4 and SMARCA2, having major effects on enhancer landscapes. Super-enhancers are a distinct subset of enhancer clusters frequently associated with oncogenes in cancer. <h4>Experimental Design</h4> SCCOHT cell lines a...

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Literature Corpus work: b78f65f8-cda7-54c5-9ac1-55b4943968d4
DOI: 10.1101/2023.09.08.556863

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