Article

WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcoma

2025-05-15

Abstract excerpt

<title>Abstract</title> <p>Background Osteosarcoma is highly invasive with a poor prognosis. The phenomenon of liquid-liquid phase separation (LLPS) can promote the formation of biomolecules and participate in the tumor regulation mechanism. Therefore, mining prognostic markers related to LLPS could allow patients to benefit from targeted therapies. Method Microarray analysis was performed to identify LLPS-rela...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9f9dc9c-0957-5e59-9e56-45f71b30d571
DOI: 10.21203/rs.3.rs-6611672/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcomaDOI 10.21203/rs.3.rs-6611672/v1Read

Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcomaSemantic proximity Read

Systematic Analysis of Molecular Characterization and Clinical Relevance of Liquid–Liquid Phase Separation Regulators in Digestive System NeoplasmsSemantic proximity Read

YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancersSemantic proximity Read

Liquid‒liquid phase separation: roles and implications in future cancer treatment.Semantic proximity Read

Significance of Liquid-Liquid Phase Separation-related Genes in the Prognostic Assessment of Oral Squamous Cell Carcinoma: A Multi-omics AnalysisSemantic proximity Read

PTK6 drives HNRNPH1 phase separation to activate autophagy and suppress apoptosis in colorectal cancerSemantic proximity Read

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level RegulationSemantic proximity Read

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensatesSemantic proximity Read

Aberrant phase separation and cancer.Semantic proximity Read

A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinomaSemantic proximity Read

Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.Semantic proximity Read

Distinct roles of hnRNPH1 low-complexity domains in splicing and transcriptionSemantic proximity Read