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Article

Development and disease in a dish: the epigenetics of neurodevelopmental disorders.

Epigenomics - 1 Feb 2018

Lewis Emily Ma, Kroll Kristen L

Abstract excerpt

Human neurodevelopmental disorders (NDDs) involve mutations in hundreds of individual genes, with over-representation in genes encoding proteins that alter chromatin structure to modulate gene expression. Here, we highlight efforts to model these NDDs through in vitro differentiation of patient-specific induced pluripotent stem cells into neurons. We discuss how epigenetic regulation controls normal cortical...

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Identifiers

PMID: 29334242
DOI: 10.2217/epi-2017-0113
PMCID: PMC5810842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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