Article

Single-cell analysis of prenatal and postnatal human cortical development

2022-10-25

Abstract excerpt

We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during prenatal and postnatal developmental stages and identify lineage-specific programs that underlie the development of specific subtypes of excitatory cortical neurons, interneurons, glial cell types and brain vasculature. By leveraging single-nucleus chromatin accessibility data, we delineate enhancer-gene regulatory networks and tra...

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Literature Corpus work: 4919d3a9-63ca-5929-a7e7-b72adaefa2b2
DOI: 10.1101/2022.10.24.513555

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