Article

Autism-associated <i>NRXN1α</i> deletion rewires the H3K27me3 landscape and epigenetically disrupts human neural induction

2026-08-04

Abstract excerpt

<h4>Background</h4> Exonic deletions at the NRXN1 locus are among the most recurrent copy number variants associated with autism spectrum disorder (ASD), with most clinical deletions mapping to upstream exons and selectively disrupting NRXN1α . Although best known as a synaptic organiser, NRXN1α is transiently upregulated in neural progenitors well before synaptogenesis. Prior induced pluripotent stem cell (iPS...

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Literature Corpus work: ef4925d8-be93-50b0-990f-dffb93ad831c
DOI: 10.64898/2026.08.03.742563

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