Article

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

2020-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Genetic perturbations of cerebral cortical development can lead to neurodevelopmental disease, including autism spectrum disorder (ASD). To identify genomic regions crucial to corticogenesis, we mapped the activity of gene-regulatory elements generating a single-cell atlas of gene expression and chromatin accessibility both independently and jointly. This revealed waves of gene regulation by key...

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Literature Corpus work: d2694b41-8e6d-53c3-b963-f00d0db86ba4
DOI: 10.1101/2020.12.29.424636

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