Article

Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiation

2026-02-14

Abstract excerpt

Despite the recent identification of RFX4 as a neurodevelopmental disorder risk gene, its role in cortical development remained unclear. Here, we identified both shared and lineage-specific RFX4 requirements for human cortical development using new human stem cell models of deficiency and pathogenic mutation. We found that RFX4 restrains neurogenesis by acting cooperatively with NOTCH signaling, specifically repre...

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Literature Corpus work: 6472f28a-4030-5d66-b0f5-4bb454a5ff56
DOI: 10.64898/2026.02.11.705165

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