Article

Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome

2020-03-19

Abstract excerpt

<h4>Summary</h4> X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby genes from one X chromosome are repressed. Analysis of human induced pluripotent stem cell (iPSC) lines using proteomics, RNAseq and polysome profiling showed a major change in the proteome upon XCI erosion. This resulted in amplified RNA and protein expression from X-linked genes. However, increased prot...

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Literature Corpus work: b7d95456-6bdf-5f32-bb97-175cb67190f4
DOI: 10.1101/2020.03.18.997049

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