Article

A human induced pluripotent stem cell toolbox for studying sex chromosome effects

2025-03-03

Abstract excerpt

<h4>Summary</h4> Sex chromosomes shape male (XY) - female (XX) differences in development and disease. These differences can be modelled in vitro by comparing XY and XX human induced pluripotent stem cells (hiPSCs). However, in this system, inter-individual autosomal variation and unstable X-dosage compensation can confound identification of sex chromosomal effects. Here, we utilise sex chromosome loss in XXY fi...

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Literature Corpus work: 133da91b-650a-5f34-a086-0227325dfd8e
DOI: 10.1101/2025.02.28.640277

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