Article

GCNA interacts with Spartan and Topoisomerase II to regulate genome stability

2019-03-07

Abstract excerpt

<h4>Summary</h4> GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan/DVC-1 and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication. We show that GCNA and Topoisomerase 2 (Top2) physically interact and colocalize on condensed chromosomes during mitosis, when Spartan is not present. We sh...

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Literature Corpus work: b7c3e49e-5c9d-5166-9fd4-0f0a246cb362
DOI: 10.1101/570200

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