Article

The histone chaperone activity of SPT2 controls chromatin structure and function in Metazoa

2023-02-16

Abstract excerpt

Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3-H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Here we identify the Caenorhabditis elegans orthologue of SPT2 (CeSPT-2) and show that its ability to bind histones H3-H4 is important for germline development and transgeneration...

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Literature Corpus work: c0b5f527-9a63-5d8d-b300-05715cb2dc40
DOI: 10.1101/2023.02.16.528451

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