Article

A single H2A variant prevents genome instability through piRNAs biogenesis and replication stress control.

2026-05-21

Abstract excerpt

Transposable elements (TEs) pose a major threat to genome integrity in the germline, where the piRNA pathway ensures heritable TEs silencing. How the chromatin environment that enables piRNA biogenesis is first established during oogenesis remains unclear. Here, we identify the histone variant His2Av, the single H2A variant in Drosophila combining H2A.Z (transcriptional) and H2A.X (DNA repair) features, as a criti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07264e9c-380f-5033-9897-5d920ef0e8ee
DOI: 10.64898/2026.05.19.726330

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single H2A variant prevents genome instability through piRNAs biogenesis and replication stress control.DOI 10.64898/2026.05.19.726330Read

In the <i>Drosophila</i> germline H2Av and Arp6 suppress transposons by driving piRNA pathway expressionSemantic proximity Read

The histone demethylase KDM3 prevents auto-immune piRNAs production in <i>Drosophila</i>Semantic proximity Read

Role of ADMA-histones in dual-strand piRNA source loci recognition by RhinoSemantic proximity Read

The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clustersSemantic proximity Read

RDC complex executes a dynamic piRNA program during <i>Drosophila</i> spermatogenesis to safeguard male fertilitySemantic proximity Read

Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in <i>Drosophila melanogaster</i>Semantic proximity Read

Escalation of genome defense capacity enables control of an expanding meiotic driverSemantic proximity Read

Splice Variants of the SWR1-type Nucleosome Remodeling Factor Domino Have Distinct Functions during <i>Drosophila melanogaster</i> OogenesisSemantic proximity Read

Transposon silencing in the <i>Drosophila</i> female germline ensures genome stability in progeny embryosSemantic proximity Read

VCP acts downstream of tTAFs to downregulate mono-ubiquitinated H2A and promote spermatocyte differentiation in <i>Drosophila</i>Semantic proximity Read

Rapid disassembly and Piwi-independent reassembly of <i>Drosophila</i> piRNA cluster heterochromatin following acute heat shockSemantic proximity Read

ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germlineSemantic proximity Read