Article
GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.
Developmental cell - 6 Jan 2020
Dokshin Gregoriy A, Davis Gregory M, Sawle Ashley D, Eldridge Matthew D, Nicholls Peter K, Gourley Taylin E, Romer Katherine A, Molesworth Luke W, Tatnell Hannah R, Ozturk Ahmet R, de Rooij Dirk G, Hannon Gregory J, Page David C, Mello Craig C, Carmell Michelle A
Abstract excerpt
GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication. Here, we show that GCNA mutants in mouse and C. elegans display defects in genome maintenance including DNA damage, aberrant chromosome condensation, and crossover...
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