Article
X Chromosome Crossover Formation and Genome Stability in Caenorhabditis elegans Are Independently Regulated by xnd-1.
G3 (Bethesda, Md.) - 7 Dec 2016
McClendon T Brooke, Mainpal Rana, Amrit Francis R G, Krause Michael W, Ghazi Arjumand, Yanowitz Judith L
Abstract excerpt
The germ line efficiently combats numerous genotoxic insults to ensure the high fidelity propagation of unaltered genomic information across generations. Yet, germ cells in most metazoans also intentionally create double-strand breaks (DSBs) to promote DNA exchange between parental chromosomes, a process known as crossing over. Homologous recombination is employed in the repair of both genotoxic lesions and...
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