Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients

Abstract excerpt

Elucidating crucial driver genes is paramount for understanding the cancer origins and mechanisms of progression, as well as selecting targets for molecular therapy. Cancer genes are usually ranked by the frequency of mutation, which, however, does not necessarily reflect their driver strength. Here we hypothesize that driver strength is higher for genes that are preferentially mutated in patients with few driver...

Topics

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• Algorithms
• Biomarkers, Tumor
• Gene Regulatory Networks
• Mutation
• Mutation Rate
• Neoplasms
• Oncogenes
• Proteins

Identifiers and source

Literature Corpus work

b7ac29dc-d180-5f46-be06-f1e2cf3cea51

DOI

10.1101/2021.08.01.21261447