Article
Comprehensive patient-level classification and quantification of driver events in TCGA PanCanAtlas cohorts.
PLoS genetics - 1 Jan 2022
Vyatkin Alexey D, Otnyukov Danila V, Leonov Sergey V, Belikov Aleksey V
Abstract excerpt
There is a growing need to develop novel therapeutics for targeted treatment of cancer. The prerequisite to success is the knowledge about which types of molecular alterations are predominantly driving tumorigenesis. To shed light onto this subject, we have utilized the largest database of human cancer mutations-TCGA PanCanAtlas, multiple established algorithms for cancer driver prediction (2020plus, CHASMplus,...
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