Article
Comprehensive identification of mutational cancer driver genes across 12 tumor types.
Scientific reports - 2 Oct 2013
Tamborero David, Gonzalez-Perez Abel, Perez-Llamas Christian, Deu-Pons Jordi, Kandoth Cyriac, Reimand Jüri, Lawrence Michael S, Getz Gad, Bader Gary D, Ding Li, Lopez-Bigas Nuria
Abstract excerpt
With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous molecular nature of the disease and the limitations of available computational methods. Here we show that the combination of complementary methods allows identifying a comprehensive and...
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