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Article

Pan-cancer detection of driver genes at the single-patient resolution.

Genome medicine - 1 Feb 2021

Nulsen Joel, Misetic Hrvoje, Yau Christopher, Ciccarelli Francesca D

Abstract excerpt

BACKGROUND: Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify driver genes that are recurrently altered across patient cohorts. However, mapping these genes back to patients leaves a sizeable fraction with few or no drivers, hindering our understanding of cancer mechanisms and limiting the choice of...

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Identifiers

PMID: 33517897
DOI: 10.1186/s13073-021-00830-0
PMCID: PMC7849133

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