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Article

Novel ratio-metric features enable the identification of new driver genes across cancer types.

Scientific reports - 7 Jan 2022

Sudhakar Malvika, Rengaswamy Raghunathan, Raman Karthik

Abstract excerpt

An emergent area of cancer genomics is the identification of driver genes. Driver genes confer a selective growth advantage to the cell. While several driver genes have been discovered, many remain undiscovered, especially those mutated at a low frequency across samples. This study defines new features and builds a pan-cancer model, cTaG, to identify new driver genes. The features capture the functional impact of...

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Identifiers

PMID: 34997044
DOI: 10.1038/s41598-021-04015-y
PMCID: PMC8741763

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