Article
Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients.
PeerJ - 1 Jan 2022
Belikov Aleksey V, Vyatkin Alexey D, Leonov Sergey V
Abstract excerpt
Background: Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver strength. We hypothesize that driver strength is higher for genes preferentially mutated in patients with few driver mutations overall, because these few mutations should be strong enough to initiate cancer. Methods: We propose formulas for the Driver Strength Index (DSI) and the Normalized...
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