Article
Cancer driver mutations: predictions and reality.
Trends in molecular medicine - 1 Jul 2023
Ostroverkhova Daria, Przytycka Teresa M, Panchenko Anna R
Abstract excerpt
Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of them drive cancer progression, termed driver mutations. Driver mutations may vary between cancer types and patients, can remain latent for a long time and become drivers at particular cancer stages, or may drive oncogenesis only in conjunction with other mutations. The high mutational, biochemical, and histological tumor...
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