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Article

Comprehensive evaluation of computational methods for predicting cancer driver genes.

Briefings in bioinformatics - 10 Mar 2022

Shi Xiaohui, Teng Huajing, Shi Leisheng, Bi Wenjian, Wei Wenqing, Mao Fengbiao, Sun Zhongsheng

Abstract excerpt

Optimal methods could effectively improve the accuracy of predicting and identifying candidate driver genes. Various computational methods based on mutational frequency, network and function approaches have been developed to identify mutation driver genes in cancer genomes. However, a comprehensive evaluation of the performance levels of network-, function- and frequency-based methods is lacking. In the present...

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PMID: 35037014
DOI: 10.1093/bib/bbab548
PMCID: PMC8921613

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