Article
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
Developmental cell - 12 Jun 2012
Suijkerbuijk Saskia J E, van Dam Teunis J P, Karagöz G Elif, von Castelmur Eleonore, Hubner Nina C, Duarte Afonso M S, Vleugel Mathijs, Perrakis Anastassis, Rüdiger Stefan G D, Snel Berend, Kops Geert J P L
Abstract excerpt
Chromosomal stability is safeguarded by a mitotic checkpoint, of which BUB1 and Mad3/BUBR1 are core components. These paralogs have similar, but not identical, domain organization. We show that Mad3/BUBR1 and BUB1 paralogous pairs arose by nine independent gene duplications throughout evolution, followed by parallel subfunctionalization in which preservation of the ancestral, amino-terminal KEN box or kinase...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Chromosome Segregation
- Gene Duplication
- Humans
- Lizards
- M Phase Cell Cycle Checkpoints
- Molecular Sequence Data