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Article

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

25 Mar 2013

Abstract excerpt

BUBR1 is a mitotic phosphoprotein essential for the maintenance of chromosome stability by promoting chromosome congression and proper kinetochore-microtubule (K-fiber) attachment, but the underlying mechanism(s) has remained elusive. Here we identify BUBR1 as a binding partner of the B56 family of Protein Phosphatase 2A regulatory subunits. The interaction between BUBR1 and the B56 family is required for...

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PMID: 23789096
DOI: 10.1242/bio.20134051

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