Article

Dissection of the Spindle Assembly Checkpoint by Proximity Proteomics

2020-06-05

Abstract excerpt

<h4>SUMMARY</h4> The spindle assembly checkpoint (SAC) is critical for sensing defective microtubule-kinetochore attachments and tension across the kinetochore and functions to arrest cells in prometaphase to allow time to repair any errors prior to proceeding into anaphase. The SAC has a central role in ensuring the fidelity of chromosome segregation and its dysregulation has been linked to the development of hu...

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Literature Corpus work: 83b6bd66-fb08-503e-81ca-e27991bf1809
DOI: 10.1101/2020.06.04.133710

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