Article

HiCP2GAN: A Plug and Play Foundation Model-based GAN for Hi-C Enhancement

2026-05-20

Abstract excerpt

The three-dimensional organization of chromatin shapes gene regulation and cellular function. Hi-C has emerged as the primary technique for mapping chromatin interactions genome-wide, yet high-resolution data remain costly and scarce, leaving many studies with sparse contact maps that limit downstream analysis. Deep learning methods, especially generative adversarial networks (GANs), have shown promise for enhanci...

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Literature Corpus work: b78951d4-6b72-5416-a134-6aca47282ed9
DOI: 10.64898/2026.05.18.725960

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