Article

scGrapHiC : Deep learning-based graph deconvolution for Hi-C using single cell gene expression

2024-02-10

Abstract excerpt

Single-cell Hi-C (scHi-C) protocol helps identify cell-type-specific chromatin interactions and sheds light on cell differentiation and disease progression. Despite providing crucial insights, scHi-C data is often underutilized due the high cost and the complexity of the experimental protocol. We present a deep learning framework, scGrapHiC, that predicts pseudo-bulk scHi-C contact maps using pseudo-bulk scRNA-seq...

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Literature Corpus work: 8d817474-2bc4-5ee2-87e5-7e7960a9e2e4
DOI: 10.1101/2024.02.07.579342

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