Article

Puget predicts gene expression across cell types using sequence and 3D chromatin organization data

2025-11-20

Abstract excerpt

Gene expression is governed by both linear DNA sequence and three-dimensional (3D) chromatin architecture. Most gene expression prediction models rely on sequence alone, thereby failing to capture structural context and to generalize to unseen cell types. We present Puget, a deep learning model that predicts cell type-specific gene expression from sequence and Hi-C data, which captures 3D chromatin organization. P...

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Literature Corpus work: fdce5ef6-3e05-5d05-8826-91de43dbb902
DOI: 10.1101/2025.11.19.689320

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