Article

A Chromatin-Structure-Guided Framework for Predictive and Interpretable Regulatory Genomics

2025-11-05

Abstract excerpt

Chromatin organization shapes gene regulation by linking distal elements across megabase scales, yet most predictive genomics models still treat the genome as linear, without incorporating three-dimensional structure. Hi-C provides genome-wide chromatin conformation information, but its contact maps are population-averaged, distance-biased, and noisy, obscuring the biologically specific contacts. We present CHROME...

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Literature Corpus work: 0b8e8aa0-7ec8-5201-b554-63c2c94a01fb
DOI: 10.1101/2025.11.03.686435

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