Article

ScHiCAtt: Enhancing Single-Cell Hi-C Resolution Using Attention-Based Models

2024-12-20

Abstract excerpt

The spatial organization of chromatin is fundamental to gene regulation and essential for proper cellular function. The Hi-C technique remains the leading method for unraveling 3D genome structures; however, limited resolution, data sparsity, and incomplete coverage in single-cell Hi-C data pose significant challenges for comprehensive analysis. Traditional CNN-based models often suffer from blurring and loss of f...

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Literature Corpus work: 3dc2177c-468c-55f2-ab2e-9b7b883e6f2c
DOI: 10.1101/2024.12.16.628505

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