Article

Orthogonal Contributions of Genetic, Clinical, and Social Determinants of Health Risk Burdens on Alzheimer’s Disease Pathophysiology

2026-07-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Alzheimer’s disease (AD) arises from complex interactions among genetic, clinical, and social determinants of health (SDoH) risk factors, yet their independent contributions to underlying AD pathophysiology remain elusive. <h4>Objective</h4> To quantify the effects of risk factors across amyloid (Aβ)/tau, neurodegeneration, and cognition. <h4>Design</h4> Cross-sectional an...

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Literature Corpus work: b777cfe0-6664-5cbd-bd14-6c79623cf674
DOI: 10.64898/2026.07.07.26357509

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